CopciAB_278770
Coprinopsis cinerea A43mutB43mut pab1-1 #326

General data

Systematic name CopciAB_278770 Strain Coprinopsis cinerea Okayama 7
Standard name PDK2 Synonyms 278770
Uniprot id Functional description Pyruvate dehydrogenase kinase
Location scaffold_8:370274..375254 Strand -
Gene length (nt) 4981 Transcript length (nt) 2091
CDS length (nt) 1326 Protein length (aa) 441

Reciprocal best hits in model fungi

Strain name Gene / Protein name
Schizosaccharomyces pombe pkp1
Neurospora crassa stk-48

Orthologs in mushroom models

Strain name Gene / Protein name Pident E-value Bits
Agrocybe aegerita Agrae_CAA7270019 86.7 1.825E-267 816
Hypsizygus marmoreus strain 51987-8 Hypma_RDB30146 84.6 1.036E-257 788
Agaricus bisporus var bisporus (H97) Agabi_varbisH97_2_179568 84 2.081E-253 775
Pleurotus eryngii ATCC 90797 Pleery1_1450931 84 8.264E-250 765
Schizophyllum commune H4-8 Schco3_2636918 81.6 2.477E-247 758
Pleurotus ostreatus PC15 PleosPC15_2_1091974 83.3 2.048E-246 755
Pleurotus ostreatus PC9 PleosPC9_1_117863 83.1 2.195E-245 752
Ganoderma sp. 10597 SS1 v1.0 Gansp1_131731 77.4 2.441E-236 726
Lentinula edodes NBRC 111202 Lenedo1_385910 74.2 7.071E-234 719
Lentinula edodes W1-26 v1.0 Lentinedodes1_7918 74.2 7.017E-234 719
Agaricus bisporus var. burnettii JB137-S8 Agabi_varbur_1_123518 82.8 1.45E-231 712
Auricularia subglabra Aurde3_1_1277389 75.2 9.687E-227 699
Flammulina velutipes Flave_chr10AA01648 75 2.534E-200 622
Grifola frondosa Grifr_OBZ65099 77.4 3.567E-187 584
Lentinula edodes B17 Lened_B_1_1_6294 78.2 8.347E-157 496

Expression

Name Summary Attribution Assay type
Carbon metabolism Transcriptional changes along alternative morphogenetic paths of C. cinerea Xie et al. 2020 RNA-Seq
Sample Mean cpm SD cpm Se of mean
sclerotia 25.0111 2.7385 1.5811
oidia 42.2633 5.3397 3.0829
vegetative_mycelium 39.1173 2.7544 1.5902
primordia 75.4092 8.4445 4.8754
hyphal_knot 34.2817 2.6422 1.5254
young_fruiting_body 100.6717 18.3229 10.5788
Complex carbon sources 1 (long incubation) Expression profiling on diverse complex carbon sources. Hegedus et al. RNA-Seq
Sample Mean cpm SD cpm Se of mean
Control - glucose 67.9598 5.6967 3.289
Wheat bran 68.0263 10.572 6.1037
Horse manure 77.0549 23.751 13.7126
Oak leaves 125.9156 74.1181 42.7921
Hay 91.3959 13.6828 7.8998
Corn stalk 68.5268 7.6039 4.3901
Pectine 73.0107 4.7697 2.7538
Microcrystalline cellulose 99.1787 25.2327 14.5681
Xylose 75.7966 5.7262 3.306
Cellobiose 65.8826 0.8219 0.4745
Lignin 114.29 13.2748 7.6642
Apple peels 62.3071 5.1258 2.9594
Coprinopsis challenged with bacteria Transcriptional response to Bacillus subtilis and Escherichia coli. Kombrink et al. 2018 RNA-Seq
Sample Mean cpm SD cpm Se of mean
Control 66.9677 4.7453 2.7397
Bsubtilis 67.7969 5.7537 3.3219
Ecoli 96.5608 4.7842 2.7622
Early development 1 Time series expression profiling of basidiospore and oidium germination Hegedus et al. QuantSeq
Sample Mean cpm SD cpm Se of mean
BS 0h 51.5003 4.1834 2.4153
BS 4h 60.9185 9.0396 5.219
BS 8h 33.0555 10.4724 6.0462
BS 12h 29.4661 1.817 1.049
Oidia 0 h 195.1729 49.7271 28.7099
Oidia 18 h 37.0012 3.2369 1.8688
Sclerotia 24.5938 1.2313 0.7109
Early development 2 Time series expression profiling of mycelial growth, light induction and fruiting body initiation. Hegedus et al. QuantSeq
Sample Mean cpm SD cpm Se of mean
DM 12h 55.334 8.7989 5.08
DM 36h 45.2195 10.9592 6.3273
DM 60h 51.4966 5.7611 3.3262
DM 84h 51.1421 6.8583 3.9596
DM 108h 45.8566 5.9359 3.4271
DM 132h 32.7295 4.3913 2.5353
DM 156hAE 32.9365 4.2186 2.4356
ELI1hAE 42.3999 9.3097 5.375
ELI2hAE 40.6942 4.3345 2.5025
LI2hAE 45.152 2.5464 1.4702
LI6hAE 41.2312 2.3837 1.3762
LI12hAE 37.0972 3.0142 1.7403
LI18hAE 26.3731 8.2281 4.7505
LI 24hAE 22.5552 10.2997 5.9465
DM 156hAM 26.0875 3.3703 1.9459
ELI1hAM 26.0876 7.6791 4.4335
ELI2hAM 41.9284 0.504 0.291
LI2hAM 38.6541 9.3774 5.4141
LI6hAM 39.8642 12.4814 7.2061
LI12hAM 23.9867 1.981 1.1437
LI18hAM 35.9744 5.4868 3.1678
LI 24hAM 22.9046 7.8065 4.5071
LI 24hHK 16.2561 6.3024 3.6387
L/D 6h 26.9751 6.0678 3.5032
L/D 12h 27.0635 6.3442 3.6628
L/D 18h 35.0874 8.6369 4.9865
L/D 24h 51.8057 1.1318 0.6534
Fruiting body development RNA-Seq analysis of fruiting body development Krizsan et al. 2019 RNA-Seq
Sample Mean cpm SD cpm Se of mean
Vegetative mycelium 46.0301 12.6821 7.322
Hyphal knots 129.7277 73.7592 42.5849
Primordium 1 59.8024 11.8169 6.8225
Primordium 2 97.5887 68.6569 39.6391
Young Fruiting body cap 149.3896 44.0357 25.424
Younf fruiting body gill 92.8779 21.7632 12.565
Young fruiting body stipe 177.8978 55.3016 31.9284
Mature fruiting body cap_gill 273.9146 31.4638 18.1656
Mature fruiting body stipe 1048.035 81.3526 46.9689
Nitrogen sources (12h incubation) Expression profiling on diverse nitrogen sources. Hegedus et al. RNA-Seq
Sample Mean cpm SD cpm Se of mean
Complete medium - control 83.0453 33.8196 19.5257
NH4NO3 51.191 9.0806 5.2427
Proline 66.6893 7.3268 4.2301
Tryptophan 48.5858 16.0449 9.2635
Isoleucin 61.0029 6.0678 3.5032
Arginine 79.3261 4.6325 2.6746
Metionine 85.0089 5.4323 3.1363
NaNO3 89.0883 7.4112 4.2789
Plant biomass (12h incubation) Expression profiling on diverse plant biomasses as carbon sources. Hegedus et al. RNA-Seq
Sample Mean cpm SD cpm Se of mean
Glucose - control 83.0453 33.8196 19.5257
Citrus peel 147.9042 30.946 17.8667
Poplar leaves 71.1114 4.1538 2.3982
Typha leaves 83.397 16.478 9.5136
Overwintered Salix leaves 88.0977 17.77 10.2595
Reed flowering 109.8999 41.4561 23.9347
Tigernut 118.2496 11.5722 6.6812
Energy cane 61.4178 10.0275 5.7894
Guar gum 61.4528 22.9956 13.2765
Apple peels 52.1256 9.4819 5.4744
Cellobiose 62.1282 7.3421 4.2389
Corn stalk 50.7095 6.9899 4.0356
Horse manure 73.6314 6.4371 3.7165
Lignin 108.3053 49.4335 28.5404
Microcrystalline cellulose 80.1428 31.4918 18.1818
Oak leaves 68.8576 10.9185 6.3038
Pectin esterified 80.5919 21.1181 12.1925
Poplar sawdust 45.1101 11.0661 6.389
Wheat bran 60.9511 10.0276 5.7894
Chlamydomonas reinhardtii 67.5889 4.2696 2.4651
Vertatryl alcohol 84.2542 14.3298 8.2733
Furfural 161.6861 27.1007 15.6466
Autoclaved mycelium 109.426 28.44 16.4198
Simple and complex carbon and nitrogen sources Expression profiling on diverse complex carbon and nitrogen sources. Hegedus et al. RNA-Seq
Sample Mean cpm SD cpm Se of mean
Glucose control 55.5509 1.4581 0.8419
Ribose 63.4956 8.3592 4.8262
Mannose 61.4894 2.1319 1.5075
Fructose 49.7132 2.0304 1.1723
Arabinose 60.8272 7.1305 4.1168
Xylose 54.5055 5.9727 3.4483
Galacturonic acid 61.5208 4.4738 2.5829
Rhamnogalacturonan 57.7045 6.1811 3.5687
Pectin esterified 55.6245 3.5797 2.0667
Polygalacturonic acid 50.5217 3.7826 2.1839
Sodium acetate 71.003 6.6903 3.8627
No nitrogen 68.1837 2.3133 1.3356
BSA 52.8585 5.9718 3.4478
Glutamine 54.167 1.7052 0.9845
No phosphate 60.2316 4.6116 2.6625
No carbon 62.1523 1.8927 1.3383
No sulphur 66.1806 2.3794 1.3738
Simple and complex carbon sources (12h incubation) Expression profiling on diverse complex carbon sources. Hegedus et al. RNA-Seq
Sample Mean cpm SD cpm Se of mean
Glucose - control 83.0453 33.8196 19.5257
Amylose 38.8939 2.3917 1.3809
Fucose 36.6266 1.2902 0.7449
Galactose 42.2688 1.3185 0.7612
Lactose 38.7115 4.0398 2.3324
Maltose 44.4279 4.703 2.7153
Mannitol 42.0402 6.4534 3.7259
Rhamnose 46.9679 12.0325 6.947
Sorbitol 30.9504 3.2842 1.8961
Trehalose 36.9991 2.7609 1.594
Glycerol 52.7257 20.9998 12.1242
Glucuronic acid 43.2958 3.9925 2.3051
Arabinan 47.9598 12.6123 7.2817
Galactan 78.2347 4.8005 2.7716
Galactomannan 55.7518 7.4285 4.2889
Glucan 57.0123 11.5736 6.682
Xylan 61.6289 8.7766 5.0672
Xyloglucan 60.3255 7.1775 4.1439
Arabinogalactan 52.5802 5.7768 3.3352
Pectin 52.1091 10.7366 6.1988
Rhamnogalacturonan 72.3453 13.665 7.8895
Polygalacturonic acid 52.8345 9.6865 5.5925
Mannan 40.9983 9.2971 5.3677
Amylopectin 44.1247 10.3566 5.9794
Inulin 41.6078 2.6132 1.5088
BSA 265.286 13.255 7.6528
Starvation induced by water agar transfer Expression profiling on starvation induced by transfer to water agar Hegedus et al. QuantSeq
Sample Mean cpm SD cpm Se of mean
Control 51.4966 5.7611 3.3262
2h WAT 40.5279 5.1454 2.9707
4h WAT 42.3998 16.7199 9.6532
8h WAT 29.9311 9.5454 5.5111
16h WAT 31.7346 6.8214 3.9384
24h WAT 25.0222 5.8799 3.3948
WAT hyphal knot -30h 29.492 7.4829 4.3203
WAT hyphal knot -22h 45.3906 4.1098 2.3728
WAT hyphal knot -15h 38.3364 5.9815 3.4534
WAT hyphal knot -7.5h 25.0538 16.3738 9.4534
WAT hyphal knot 22.5656 2.8356 1.6372
WAT hyphal knot +7.5h 20.1479 10.0468 5.8005
Straw time series Time series expression profiling on straw as a carbon source Hegedus et al. RNA-Seq
Sample Mean cpm SD cpm Se of mean
Glucose control 61.6619 30.3341 17.5134
Straw 3h 148.4789 29.6356 17.1101
Straw 6h 114.9115 14.2816 8.2455
Straw 12h 114.0643 27.4326 15.8382
Straw 24h 116.9093 41.7116 24.0822
Stress conditions 1 Expression profiling under various stress conditions Hegedus et al. QuantSeq
Sample Mean cpm SD cpm Se of mean
Flask control 49.0398 12.2014 7.0445
Frost (-20C, 30min) 20.9262 1.6206 0.9356
Heat shock (47C, 2h) 118.7917 9.7784 5.6456
High CO2 24.3673 3.7899 2.1881
Drought (4% agar, 12h) 33.3891 7.2835 4.2051
Oxidative (1mM H2O2, 3h) 73.1708 9.7125 5.6075
Acidic (pH4, 3h) 49.5624 6.4001 3.6951
Alkaline (pH9, 3h) 34.9423 2.8846 1.6654
Osmotic (sorbitol 2h) 66.9917 8 4.6188
CongoRed (3h) 42.9949 3.0155 1.741
Cobalt chloride control 22.8515 2.4962 1.4412
Cobalt chloride 2mM 21.3884 3.0834 1.7802
Stress conditions 2 Expression profiling under various stress conditions Hegedus et al. QuantSeq
Sample Mean cpm SD cpm Se of mean
Flask control 33.9567 26.6218 15.3701
Cold stimulation 34.1221 3.4436 1.9882
Scratched surface 24.5824 1.9659 1.135
Ca2+, 200mM, 24h 31.6866 0.952 0.5496
Cu2+, 2mM, 6h 51.2862 6.4249 3.7094
Voriconazole 81.0844 8.1249 4.6909
Trichoderma interaction, early 32.3797 1.7055 0.9847
Trichoderma interaction 60h 129.6028 34.7907 20.0864
Cobalt chloride 2mM repeat 54.8177 6.9811 4.0305
Hypoxia 27.3674 5.1349 2.9646
Hypoxia control 24.8166 4.3816 2.5297
Protoplastation control 32.363 4.178 2.9543
Protoplastation 3.5h 190.434 93.3034 65.9754
Protoplastation 1.5h 111.0097 35.7133 25.2531

General data

Systematic name PDK2
Protein id CopciAB_278770.T0
Description Pyruvate dehydrogenase kinase

Annotation summary

0 100 200 300 400 441

Conserved domains

Analysis Signature accession Signature description InterPro Accession Start End
CDD cd16929 HATPase_PDK-like - 261 431
Pfam PF10436 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase IPR018955 25 257
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 303 431

SignalP

Prediction Start End Score
No records

Transmembrane domains

Domain n Start End Length
No records

InterPro

Accession Description
IPR036890 Histidine kinase/HSP90-like ATPase superfamily
IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
IPR003594 Histidine kinase/HSP90-like ATPase
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
IPR039028 PDK/BCKDK protein kinase
IPR005467 Histidine kinase domain

GO

Go id Term Ontology
GO:0004672 protein kinase activity MF

KEGG

KEGG Orthology
K00898

EggNOG

COG category Description
T Pyruvate dehydrogenase kinase

CAZy

Class Family Subfamily
No records

Transcription factor

Group
No records

Conservation of CopciAB_278770 across fungi.

Arrow shows the origin of gene family containing CopciAB_278770.

Protein

Sequence id CopciAB_278770.T0
Sequence >CopciAB_278770.T0
MSAGFRITPALWDKIHHFASFPQTGVSLQQMVLFGQNPSQGTLLKASQFLSEELPVRLAHRVKELDELPHNLSDM
PSIKRVKNWYAQSFEELINFPHPQLPPEIRQALITSRSDELALPESKPNPSLIDTIYGSSPSNGNGNGGNGFNKL
RLRVPMERRYYANTSNITHWPPEVQDYNKRFTKLLEHIKSRHDPTVTTVAQGVLEWKRSQNARHIGLDIQAWLDR
FYMSRIGIRFLIGQHVALNTQQAHEDYVGIICTKANVHDIVQEAIENARFVCEEHYAMFKGPPVQLICPPSLTFA
YVPGHLSHICFELLKNSLRAVVERYGVDAEDHFPPIKVIVVEGKEDITIKISDEGGGIARSAIPLIWTYMYTTME
HQTSLDEDFQASDFKAPMAGFGYGLPLSRLYARYFGGDLRLIAMDGFGTDVYIHLNRLSSSREPLP
Length 441

Coding

Sequence id CopciAB_278770.T0
Sequence >CopciAB_278770.T0
ATGTCGGCGGGATTCAGGATAACACCAGCCCTATGGGACAAGATTCACCATTTTGCGTCCTTTCCTCAGACGGGA
GTGTCACTGCAGCAGATGGTGTTGTTCGGTCAGAATCCCAGTCAAGGGACGTTGTTGAAAGCGAGTCAGTTTCTA
TCAGAGGAACTGCCTGTACGACTGGCACATCGAGTAAAGGAACTCGACGAGCTACCGCACAATTTGAGCGACATG
CCGTCCATCAAGCGCGTGAAGAACTGGTATGCCCAGTCGTTTGAGGAACTAATAAACTTCCCGCACCCGCAACTC
CCGCCTGAAATCCGCCAAGCACTCATCACCTCCCGATCCGACGAACTCGCCCTCCCAGAATCCAAACCAAACCCT
TCCTTGATAGATACCATCTACGGTTCCTCGCCTTCCAACGGTAATGGAAATGGGGGTAACGGTTTCAACAAGCTG
AGGCTGAGAGTGCCTATGGAGCGGAGATACTACGCTAATACCTCCAATATCACACATTGGCCACCCGAAGTGCAA
GACTACAACAAGCGATTTACAAAGTTGCTGGAGCATATCAAGTCTAGACATGACCCGACTGTTACCACCGTTGCT
CAGGGCGTCCTCGAATGGAAACGTTCCCAAAACGCACGACATATCGGGTTAGATATCCAAGCGTGGTTGGATCGG
TTTTATATGAGTCGGATTGGGATTCGGTTTTTGATTGGGCAGCATGTGGCGCTGAACACGCAACAAGCTCATGAA
GATTATGTGGGGATTATTTGTACGAAAGCTAACGTGCACGACATTGTGCAAGAAGCGATTGAGAATGCTCGATTT
GTGTGTGAAGAGCATTATGCGATGTTCAAAGGGCCGCCTGTGCAGTTGATTTGTCCACCTTCTTTGACATTTGCT
TATGTTCCTGGCCATTTATCACATATCTGCTTCGAGCTTCTCAAGAACTCTTTACGAGCTGTTGTGGAACGGTAT
GGTGTGGATGCGGAGGACCATTTCCCGCCTATCAAGGTCATCGTTGTAGAGGGAAAGGAGGATATCACGATCAAG
ATTAGTGATGAGGGAGGTGGGATTGCGAGGAGTGCGATTCCGTTGATTTGGACGTATATGTATACGACTATGGAG
CACCAGACAAGTTTAGACGAAGATTTCCAAGCGAGCGATTTCAAAGCTCCGATGGCTGGGTTTGGATATGGGTTG
CCTCTGAGTAGATTGTACGCAAGATATTTCGGTGGCGACCTACGGTTGATCGCGATGGATGGATTTGGGACGGAT
GTATACATCCACCTGAATAGGTTGTCGAGTAGTAGAGAACCTCTACCTTGA
Length 1326

Transcript

Sequence id CopciAB_278770.T0
Sequence >CopciAB_278770.T0
AGCTTTCCCCTCCTCATCCTCCTTGCTCCTTCTCTTGTCACAGGCATACCCTATTCTCAACTCTCTAGTTCTAGA
AACCACCACGGCGCACTTCGTAGAGATCAGGATTGTATTGGGTATTGAAGGATGTCGGCGGGATTCAGGATAACA
CCAGCCCTATGGGACAAGATTCACCATTTTGCGTCCTTTCCTCAGACGGGAGTGTCACTGCAGCAGATGGTGTTG
TTCGGTCAGAATCCCAGTCAAGGGACGTTGTTGAAAGCGAGTCAGTTTCTATCAGAGGAACTGCCTGTACGACTG
GCACATCGAGTAAAGGAACTCGACGAGCTACCGCACAATTTGAGCGACATGCCGTCCATCAAGCGCGTGAAGAAC
TGGTATGCCCAGTCGTTTGAGGAACTAATAAACTTCCCGCACCCGCAACTCCCGCCTGAAATCCGCCAAGCACTC
ATCACCTCCCGATCCGACGAACTCGCCCTCCCAGAATCCAAACCAAACCCTTCCTTGATAGATACCATCTACGGT
TCCTCGCCTTCCAACGGTAATGGAAATGGGGGTAACGGTTTCAACAAGCTGAGGCTGAGAGTGCCTATGGAGCGG
AGATACTACGCTAATACCTCCAATATCACACATTGGCCACCCGAAGTGCAAGACTACAACAAGCGATTTACAAAG
TTGCTGGAGCATATCAAGTCTAGACATGACCCGACTGTTACCACCGTTGCTCAGGGCGTCCTCGAATGGAAACGT
TCCCAAAACGCACGACATATCGGGTTAGATATCCAAGCGTGGTTGGATCGGTTTTATATGAGTCGGATTGGGATT
CGGTTTTTGATTGGGCAGCATGTGGCGCTGAACACGCAACAAGCTCATGAAGATTATGTGGGGATTATTTGTACG
AAAGCTAACGTGCACGACATTGTGCAAGAAGCGATTGAGAATGCTCGATTTGTGTGTGAAGAGCATTATGCGATG
TTCAAAGGGCCGCCTGTGCAGTTGATTTGTCCACCTTCTTTGACATTTGCTTATGTTCCTGGCCATTTATCACAT
ATCTGCTTCGAGCTTCTCAAGAACTCTTTACGAGCTGTTGTGGAACGGTATGGTGTGGATGCGGAGGACCATTTC
CCGCCTATCAAGGTCATCGTTGTAGAGGGAAAGGAGGATATCACGATCAAGATTAGTGATGAGGGAGGTGGGATT
GCGAGGAGTGCGATTCCGTTGATTTGGACGTATATGTATACGACTATGGAGCACCAGACAAGTTTAGACGAAGAT
TTCCAAGCGAGCGATTTCAAAGCTCCGATGGCTGGGTTTGGATATGGGTTGCCTCTGAGTAGATTGTACGCAAGA
TATTTCGGTGGCGACCTACGGTTGATCGCGATGGATGGATTTGGGACGGATGTATACATCCACCTGAATAGGTTG
TCGAGTAGTAGAGAACCTCTACCTTGATCGACCTTTTTTTTCGTTTTCCTTCCTGTCTATCCCACTCGTCTATCA
TCCGTCCACCCATCCGACCGACCGCCCGACCGGCTTCACTCACGCTCGCTACTGCCCATCCATCATCTCCGACCC
GCCTTATCCATTGCCATTCTGACCCGCCTTGCCTCTCCGAACCCACTGTCCTTTCGAATTTCCATTCTTGGACTG
CTATCTGAACCTCAATGGGGGTATCCCCTCTCGTTTCGTCTAAAGGAGATGACTACTCCCACACCTTGCCGATCT
CACGGATGGAGAAGCGTGGAGTTCACCGTCGATATGCTTACCGTCGACTACCACGTACCGTCTACCCACCGCGTG
GTGGGTGCTGGAGGAGCAGGAGGAAGAATCCCTGTCAGCCTAGAAGTGTATTTTGGACGGGGGACGTAGGGGTGC
GGAAGGCGTACCTTATCATCCTTTCTTTCATCCTGGCAGTTGTTGGACGGGAGGGGAGGGGAGGGGTTGGGTTGA
ACTGGACTGGACTGGACTGGAAGGAAGTGGTTCGTTCTTTCACTCCGTATCCTCATTTTTTTCCCTTTTTTTTTT
TTTGTTGTGCTGTCTGTCGTGTACCATATTTTGTAACTTAGTACAATATCACCCTTATTTACTGTT
Length 2091

Gene

Sequence id CopciAB_278770.T0
Sequence >CopciAB_278770.T0
AGCTTTCCCCTCCTCATCCTCCTTGCTCCTTCTCTTGTCACAGGCATACCCTATTCTCAACTCTCTAGTTCTAGA
AACCACCACGGCGCACTTCGTAGAGATCAGGATTGTATTGGGTATTGAAGGATGTCGGCGGGATTCAGGATAACA
CCAGCCCTATGGGACAAGATTCACCATTTTGCGTCCTTTCCTCAGACGGGAGGTGAGTACTTTCTACGTCTATCG
AGTGTACATGTCTTCACACCGCTTTCGTAGTGTCACTGCAGCAGATGGTGTTGTTCGGTCAGAATCCCAGTCAAG
GGACGTTGTTGAAAGCGAGTCAGTTTCTATCAGGTGCGTGGGTCATATGTGCCTGGATGAAGGAAAGTCGTTGTT
GATAGCGATGGTGTTACAGAGGAACTGCCTGTACGACTGGCACATCGAGTAAAGGAACTCGACGAGCTACCGCAC
AATTTGAGCGACATGCCGTCCATCAAGCGCGTGAAGAACTGGTATGCCCAGTCGTTTGAGGTCTGTATCCCACAC
ATTTCTTTGCAATGAAACATTCACTGTACCAGATGCTAACACGTATACCCTACAGGAACTAATAAACTTCCCGCA
CCCGCAACTCCCGCCTGAAATCCGCCAAGCACTCATCACCTCCCGATCCGACGAACTCGCCCTCCCAGAATCCAA
ACCAAACCCTTCCTTGATAGATACCATCTACGGTTCCTCGCCTTCCAACGGTAATGGAAATGGGGGTAACGGTTT
CAACAAGCTGAGGCTGAGAGTGCCTATGGAGCGGAGGTGAGTCGTCGTGGTTCTTTAACGAACGTTTGAGTGGGG
GTTTGTGAAGAGGGAATTGACGAATGAATTGTCGTGACAGATACTACGCTAATACCTCCAATATCACACATTGGC
CACCCGAAGTGCAAGACTACAACAAGCGATTTACAAAGTTGCTGGAGCATATCAAGTCTAGACATGACCCGACTG
TTACCACCGTTGCTCAGGGTATGTTTTGCCTCCCTTCTCTTCTCTTTTCCCTACGCTATTCTCGTCCTCTTGTTC
GTGTCCTTGGGGTGCTTCACCTCCCTTTTCTTTCTATTTCCCGCTCTAGGGCGTTCGTTTCGCCTTCCCGCCTTC
TTCGGCGTTCTGGGTGTGTTCTGGGCGTCTGGGCTCGGTTCAGTTCCCCTTCCTTCACTCTACTCCCGTTCCATG
GATCCCTTTGTGATATGTGAAGAACATGCGCTAACGGAACTATCAATTCCTTTCACTCTCCCTCAATGTCTTCAC
GCTCCCTTACTTGGCTTCCTTTCGTTGTCCTTGACGCACGCTCTCGCCTCTCGCCTGCCACCAACTTTCTTGGTT
ACTGGACCCCGCCTGCCACGAACCGACTTGCTTTGTTCCCGCCACACCATCCTTGGCTATTGGACCTCCCGCCTA
TGACGACGATATCACGCCGCCACCGCACACATCAAATCACACTCCGCGAACGCGAATGCTGCGCTCCGAATGGTC
GGAATCGCGACCCCTGCGATGGCATGGTTGGGATTCTTTCGACGTTGGAATGTATGCTTGTGATTCGGCGCTTGG
ATGGGGCGCATCTGGTGTTATTGGGATCATCTCGACCACCTTGGCTTTACGATAAATCTGCACTCGTGAACCGAC
TACCTACCGCCGAACCTTTAACCGCCCTCTGCAATTACGCGCACGCCATGCACCGATTGAACCGTATGCACCCGA
TCTATACTCACCGTCTGCGACACCATCCACCTCACCAACCACGTTCACCACCTACACTCACTAACCCTCCCTCAC
GAATCACGTCTCTCGAACTCTCTCGAACTCGCTCGATCAAAATCTAAAAAAATCCCCCCCCCCAAAAAAAAACGG
GATATTGGGATATCGGGCAAAAAAATAGGCGTCCTCGAATGGAAACGTTCCCAAAACGCACGACATATCGGGTTA
GATATCCAAGCGTGGTTGGATCGGTTTTATATGAGTCGGATTGGGATTCGGTTTTTGATTGGGCAGCGTGAGTAC
TCTGTTTTGGTTTTTTTTTTTTTTTTTTTGGTTTGCTTTGGCTTTTGGTTTTTTGTATTATTCGGGGGGAGGATT
TGGGAGTGGGACGGGGTTTATTTTTGGGAGGTGGAAGAAGAGGGTGAACGGGCGAAAATGACAGATGGGATGGGA
GGTAGGATGGGGGTGGGGTAGGTCACAGAAGTGGGATGGTGAAAGTGTTACGCGAGTGAAGGGTGAAAGATGAAA
GAGTAAGACTTGGGTTTGAAACCGTGGGGAGTTGGGTGGAACGGGCTTGGGAGAAAATGATGGTATAGCGACGAG
GACGTGGTTGGACGTATGATTTGAGATGGGATTCCGGATTTGCTGTTGCTGTTGCTTTTGCTTTTTCTGTTTCGG
AGGATTTGAACCCAGGAAGGAGACGGACCACTGATCAATTTCCGTTCATCTTTTTTTTTTCGTTTTTTGCAGATG
TGGCGCTGAACACGCAACAAGCTCATGAAGATTATGTGGGGATTATTTGTACGAAAGCTGTACGTGTTCCTCGTT
CTCTTTTTTGCTTTTTTTTTCGCTCTCCTTGTCCGTCCTGTGTGTTGTTTCTACCCTTGAGCGCGCTTTTGGGGG
GTTTGTTTTTTTCAGATTTCCGGTCTCGTTTCGATTTTGCTATCCTTCGTCCACGCCACTTCATTACCGCTGATG
TGTTCGACACGTTGGACCCGTTCCGTTCATTTGAACACTTCATGTTATCATTTCAACCTCTTCACACTTTCGACA
CGTTCCCCTTTCATCTTAAGCTTCGCCTTCACCTTTCGACACGCTCTTTCATTTTTTCGGCACTTCATCGGCAAT
TGAACCGCATACTGACGAAACCGCTTTCTTATTTCTTTTTCGTATGCGAACTCGTTGTGGTGGTGGTGGATGTTA
TCGTAATGGACACCCTGGTTGTCGTGATGCGCTCTCGTTATCTCGACTCGACTCGACTCGGTCGTTGTGATGTGT
TTGGGATCTGGTTTTGCCTTGATCTCGGTGGTTATGGTGCCATTTCTCGAACCTTTTACACCTGCGCCGTAATCT
CCGGCTTGTGGGTGTGTGTGTGTCTATTTGGCGATTTGACGGATACCCGACTCGGTGTTTTATTCGACCGTTCCG
ACCGACCGACCGACCGACACCACGTTCCAACCCATGCTACATCCCGACCTGCACCACGTCCCGACTTACACCGTG
CCAAACTGACACCACGTCCTGATCGAACGCCGCATCGTAAACGCAAACCTATTCCGAACCCCCCTCCAAAAAACA
GAACGTGCACGACATTGTGCAAGAAGCGATTGAGAATGCTCGATTTGTGTGTGAAGAGCATTATGCGATGTTCAA
AGGGCCGCCTGTGCAGTTGATTTGTCCACCTTCTTTGACATTTGCTTATGTTCCTGGTGAGTTTCTTTTCCTTTT
CCTTCTCGCCCTATGCTCCATCTAGTCTTTTTTTTTTTTTTTTCTCGATCACGATGTTTTTGTTGGTTTCTTTTT
TACTTGTTGTTATCGTACGACTTTTTTGGTGCTTCCCTCTTTCTTGCTTTGGATTTCGTGGTGCTCTATTTTGTA
AGGCTTCCATTTTGTTTTCGCCTCATGTCAACCTTGCTCGTTTCATCTCGTTCATTTCAATCTCGATTTCGTCTC
ACTTCATCTCCGTTATCTTCGTGCGATATGACATAACTCACCCCTCCCACGATGATAGGCCATTTATCACATATC
TGCTTCGAGCTTCTCAAGAACTCTTTACGAGCTGTTGTGGAACGGTATGGTGTGGATGCGGAGGACCATTTCCCG
CCTATCAAGGTCATCGTTGTAGAGGGAAAGGAGGATATCACGATCAAGATTAGTGATGAGGGAGGTGGGATTGCG
AGGAGTGCGATTCCGTTGATTTGGACGTATATGTATACGACTATGGAGGTATGAAGACGTTTCTGGCTGTTAAGG
ACCATTTGGTGCTGACGACCGCTTGATGCTTGCCACCTCTTCGATTCCTGACAGCACCAGACAAGTTTAGACGAA
GATTTCCAAGCGAGCGATTTCAAAGCTCCGATGGCTGGGTTTGGATATGGGTTGCCTCTGAGTAGATTGGTGCGT
CTCTGTCTCTCCCTTTCTCTCGCTCTCTCTCGCATTTTCGTGTTGTTGTTCCCCTCAGAGCAGATGCTGATAGCT
AACTCCCCTTTTTATTGTTTACTATTATTAGTACGCAAGATATTTCGGTGGCGACCTACGGTTGATCGCGATGGA
TGGATTTGGGACGGATGTATACATCCACCTGAATAGGTTGTCGAGTAGTAGAGAACCTCTACCTTGATCGACCTT
TTTTTTCGTTTTCCTTCCTGTCTATCCCACTCGTCTATCATCCGTCCACCCATCCGACCGACCGCCCGACCGGCT
TCACTCACGCTCGCTACTGCCCATCCATCATCTCCGACCCGCCTTATCCATTGCCATTCTGACCCGCCTTGCCTC
TCCGAACCCACTGTCCTTTCGAATTTCCATTCTTGGACTGCTATCTGAACCTCAATGGGGGTATCCCCTCTCGTT
TCGTCTAAAGGAGATGACTACTCCCACACCTTGCCGATCTCACGGATGGAGAAGCGTGGAGTTCACCGTCGATAT
GCTTACCGTCGACTACCACGTACCGTCTACCCACCGCGTGGTGGGTGCTGGAGGAGCAGGAGGAAGAATCCCTGT
CAGCCTAGAAGTGTATTTTGGACGGGGGACGTAGGGGTGCGGAAGGCGTACCTTATCATCCTTTCTTTCATCCTG
GCAGTTGTTGGACGGGAGGGGAGGGGAGGGGTTGGGTTGAACTGGACTGGACTGGACTGGAAGGAAGTGGTTCGT
TCTTTCACTCCGTATCCTCATTTTTTTCCCTTTTTTTTTTTTTGTTGTGCTGTCTGTCGTGTACCATATTTTGTA
ACTTAGTACAATATCACCCTTATTTACTGTT
Length 4981